r-Java 2.0: the nuclear physics

[Aims:] We present r-Java 2.0, a nucleosynthesis code for open use that performs r-process calculations as well as a suite of other analysis tools. [Methods:] Equipped with a straightforward graphical user interface, r-Java 2.0 is capable of; simulating nuclear statistical equilibrium (NSE), calculating r-process abundances for a wide range of input parameters and astrophysical environments, computing the mass fragmentation from neutron-induced fission as well as the study of individual nucleosynthesis processes. [Results:] In this paper we discuss enhancements made to this version of r-Java, paramount of which is the ability to solve the full reaction network. The sophisticated fission methodology incorporated into r-Java 2.0 which includes three fission channels (beta-delayed, neutron-induced and spontaneous fission) as well as computation of the mass fragmentation is compared to the upper limit on mass fission approximation. The effects of including beta-delayed neutron emission on r-process yield is studied. The role of coulomb interactions in NSE abundances is shown to be significant, supporting previous findings. A comparative analysis was undertaken during the development of r-Java 2.0 whereby we reproduced the results found in literature from three other r-process codes. This code is capable of simulating the physical environment of; the high-entropy wind around a proto-neutron star, the ejecta from a neutron star merger or the relativistic ejecta from a quark nova. As well the users of r-Java 2.0 are given the freedom to define a custom environment. This software provides an even platform for comparison of different proposed r-process sites and is available for download from the website of the Quark-Nova Project: http://quarknova.ucalgary.ca/Comment: 26 pages, 18 figures, 1 tabl

DEFCON: high-performance event processing with information security

In finance and healthcare, event processing systems handle sensitive data on behalf of many clients. Guaranteeing information security in such systems is challenging because of their strict performance requirements in terms of high event throughput and low processing latency. We describe DEFCON, an event processing system that enforces constraints on event flows between event processing units. DEFCON uses a combination of static and runtime techniques for achieving light-weight isolation of event flows, while supporting efficient sharing of events. Our experimental evaluation in a financial data processing scenario shows that DEFCON can provide information security with significantly lower processing latency compared to a traditional approach

Targeted Screening for Alzheimer's Disease Clinical Trials Using Data-Driven Disease Progression Models

Heterogeneity in Alzheimer's disease progression contributes to the ongoing failure to demonstrate efficacy of putative disease-modifying therapeutics that have been trialed over the past two decades. Any treatment effect present in a subgroup of trial participants (responders) can be diluted by non-responders who ideally should have been screened out of the trial. How to identify (screen-in) the most likely potential responders is an important question that is still without an answer. Here, we pilot a computational screening tool that leverages recent advances in data-driven disease progression modeling to improve stratification. This aims to increase the sensitivity to treatment effect by screening out non-responders, which will ultimately reduce the size, duration, and cost of a clinical trial. We demonstrate the concept of such a computational screening tool by retrospectively analyzing a completed double-blind clinical trial of donepezil in people with amnestic mild cognitive impairment (clinicaltrials.gov: NCT00000173), identifying a data-driven subgroup having more severe cognitive impairment who showed clearer treatment response than observed for the full cohort

Vision in the Southern Hemisphere Lamprey Mordacia Mordax: Spatial Distribution, Spectral Absorption Characteristics, and Optical Sensitivity of a Single Class of Retinal Photoreceptor

The dorso-laterally located eyes of the southern hemisphere lamprey Mordacia mordax (Agnatha) contain a single morphological type of retinal photoreceptor, which possesses ultrastructural characteristics of both rods and cones. This photoreceptor has a large refractile ellipsosome in the inner segment and a long cylindrical outer segment surrounded by a retinal pigment epithelium that contains two types of tapetal reflectors. The photoreceptors form a hexagonal array and attain their peak density (33,200 receptors0mm2) in the ventro-temporal retina. Using the size and spacing of the photoreceptors and direct measures of aperture size and eye dimensions, the peak spatial resolving power and optical sensitivity are estimated to be 1.7 cycles deg21 (minimum separable angle of 34'7'' ) and 0.64 mm2 steradian (white light) and 1.38 mm2 steradian (preferred wavelength or lmax), respectively. Microspectrophotometry reveals that the visual pigment located within the outer segment is a rhodopsin with a wavelength of maximum absorbance (lmax) at 514 nm. The ellipsosome has very low absorptance (,0.05) across the measured spectrum (350-750 nm) and probably does not act as a spectral filter. In contrast to all other lampreys studied, the optimized receptor packing, the large width of the ellipsosome-bearing inner segment, together with the presence of a retinal tapetum in the photophobic Mordacia, all represent adaptations for low light vision and optimizing photon capture

Spin glass or random anisotropy?: The origin of magnetically glassy behavior in nanostructured GdAl\u3csub\u3e2\u3c/sub\u3e

Initially crystalline GdAl2 was mechanically milled for long times to produce a highly chemically disordered phase with approximately 8-nm grains. Analysis of dc magnetization measurements using an Arrott plot and the approach to saturation suggest the presence of significant random anisotropy. ac susceptibility measurements showed that the shift in the peak temperature with frequency usually seen in magnetically glassy and superparamagnetic systems was virtually undetectable in the 10–1000-Hz frequency range. Based on these results, we believe that this material represents an interacting system with random anisotropy, where the anisotropy is the result of surface and interface asymmetries. ©2005 American Institute of Physic

Coulomb-Driven Cluster-Glass Behavior in Mn-Intercalated Ti1+yS2

We have investigated the low-temperature spin-glasslike phase in the intercalated transition-metal dichalcogenide Mn0.09Ti1.1S2. A departure from Curie–Weiss behavior in the paramagnetic regime indicated the formation of small ferromagnetically correlated clusters. The Vogel–Fulcher law provided an excellent description of relaxation times in the vicinity of the transition, showing that the glasslike phase occurs due to interaction between the clusters. Cole–Cole plots for data close to the transition were linear, which is consistent with a simple exponential distribution of cluster sizes. A Monte Carlo simulation of the dichalcogenide system, including excess self-intercalated Ti ions, gave an exponential cluster-size distribution for a relatively narrow range of concentration values of Mn and Ti ions, values that were consistent with those of the Mn0.09Ti1.1S2 sample. Strong commonality in the relaxation behavior with certain ferroelectric relaxor systems suggests underlying similarity in the microscopic structure of the clusters in both systems, which may be chainlike or quasi-one-dimensional